Performance evaluation of road pavement green concrete : an application of advance decision-making approach before life cycle assessment

Rigid pavement structures are one of the costly components of the infrastructure development process. It consumes a huge quantity of ingredients necessary for concrete development. Hence, a newly introduced concept of circular economy in combination with waste management was introduced to solve this problem. In this study, three waste products (rice husk ash (RHA), wood sawdust (WSD), and processes waste tea (PWT)) was utilized to develop the concrete for rigid pavement structures by replacing the sand, i.e., a filler material at different percentages. During the testing procedure of compressive (CS), tensile (TS), and flexural strength (FS) properties, RHA and WSD at 5% replacement were found to be a good replacement of sand to develop required concrete. This study will help in the production of eco-friendly rigid pavement structures and a pathway of life cycle assessment in the future

Differential Image Compression for Telemedicine: A Novel Approach

Telemedicine is one of the most emerging technologies of applied medical sciences. Medical information related to patients is transmitted and stored for references and consultations. Medical images occupy huge space; in order to transmit these images may delay the process of image transmission in critical times. Image compression techniques provide a better solution to combat bandwidth scarcity problems, and transmit same image in a much lower bandwidth requirements, more faster and at the same time maintain quality. In this paper a differential image compression method is developed in which medical images are taken from a wounded patient and are compressed to reduce the bit rate of these images. Results indicate that on average 25% compression on images is achieved with 3.5 MOS taken from medical doctors and other paramedical staff the ultimately user of the images

Designing an IT-Based System for Optimizing Lung Cancer Management

Digital health offers lung cancer patients to improve their health status while allowing patients, providers, and administrators to coordinate data and care at individual and community levels. While technology improvements provide lung cancer patients and healthcare providers with a valuable new tool for disease management, these are yet to be widely accepted. In particular, we aim to: (1) develop a Machine Learning (ML)-based framework for data collection from active online lung cancer forums and other parameters for patients, providers and their organizations, (2) build an AI-based model to develop a cancer ontology for exploring different factors and patients’ emotions associated to lung cancer management, (3) Design a mHealth app to set up a support system in terms of providing patients with information and social support, and ML models-based treatment recommendation system. The IT-based support system will provide the best and most specific treatment plan and recommendation system for lung cancer management

SOLID PHASE MICROBIAL FERMENTATION OF ANABOLIC STEROID, DIHYDROTESTOSTERONE WITH ASCOMYCETE FUNGUS FUSARIUM OXYSPORUM

Objective: Microbial catalysis is used in the commercial production of many bioactive steroids. Solid phase microbial fermentation of anabolic steroid, dihydrotestosterone (DHT, 1), was carried out with ascomycete fungal strain Fusarium oxysporum (NRRL-1392).Methods: Sabouraud-4% glucose-agar was used to cultivate the fungal cultures as solid phase medium. Substrate 1 was incubated with Fusarium oxysporum (NRRL-1392) for 8 days. Microbial transformed metabolites were purified by using column chromatographic technique. Results: Ascomycete fungal strain Fusarium oxysporum (NRRL-1392), transformed dihydrotestosterone (1) to four oxidative metabolites 2-5  using solid phase microbial transformation metod. During biotransformation process the hydroxy group was incorporated in inactivated methine carbon atoms at C-7 and C-11 positions. Their structures were elucidated by means of a homo and heteronuclear 2D NMR and by HREI-MS techniques as 17b-hydroxyandrosta-1, 4-dien-3-one 2, androsta-1, 4-diene-3, 17-dione 3, 7a, 17b-dihydroxyandrosta-1, 4-dien-3-one (4), and 11a-hydroxyandrosta-1, 4-diene-3, 17-dione 5. The relative stereochemistry of newly incorporated hydroxy groups were deduced by 2D NOESY experiment.Conclusion: In conclusion, microbial biocatalysis is an attractive alternative tool for the preparation of new bioactive steroids, which might be difficult to prepare by conventional chemical routes. Furthermore, microbial-catalyzed biotransformations can produce commercially valuable steroidal pharmaceuticals for the pharmaceutical industry.Â

SOLID PHASE MICROBIAL REACTIONS OF SEX HORMONE, TRANS-ANDROSTERONE WITH FILAMENTOUS FUNGI

Objective: A microbial biotransformation study was performed on trans-androsterone (1) using solid phase medium. In the present context, trans-androsterone (1), a sex hormone was fermented with two filamentous fungi, Rhizopus stolonifer (black bread mold) and Fusarium lini.Methods: Sabouraud-4% glucose-agar were used to cultivate the fungal cultures as solid phase medium. Substrate 1 was incubated with R. stolonifer (ATCC 10404) and F. lini (NRRL 68751) for 8 days. Microbial transformed metabolites were purified by using column chromatographic technique. Results: The metabolism study of 1 revealed that various metabolites were detected when incubated with filamentous fungi. A total of 3 transformed products were obtained. The reactions occurred that exhibited diversity; including selective hydroxylation at C-6 and C-7 along with oxidation occurs at C-3 positions. Their structure and identified on the basis of extensive spectroscopic data (NMR, HREIMS, IR and UV) as 3b,7b-dihydroxy-5a-androstan-17-one 2 in a good yield (58%), 6b-hydroxy-5a-androstan-3,17-dione 3, and 3b,6b-dihydroxy-5a-androstan-17-one 4.Conclusion: Solid phase microbial transformation method can successfully be used for the development of new steroidal drugs. The modified steroidal molecules could favor when compared to their natural counterparts due to several medicinal advantages.Â

Prevalent distribution of conscious processes on either side of the brain

Objectives. The brain has an intrinsic tendency for the lateralization of its functions. For instance, the left hemisphere assists in the comprehension and motor expression of language. What remains uncertain is whether conscious processes are also more prevalent in one hemisphere of the brain than the other. The epistemic goal of this research was to address this particular issue. Materials and Methods. We observed the rare pathological event of proximal occlusion of the middle cerebral artery (MCA), which halts blood flow to the central two-thirds of a hemisphere, and examined its effects on consciousness. We aggregated individual scores for eyes-opening and limb-motor responses from the Glasgow Coma Scale (GCS) to determine the conscious level, and used brain computed tomography imaging to identify the whole-territory infarcts of MCA. Results. Being a rare condition, we managed to recruit 35 patients from two centers (average age: 64.54 ± 13 years, 45.71% females). Whole-territory infarcts of the MCA occurred more frequently in the left hemisphere (22 versus 13, frequency: 62.85%). Unconsciousness was also more common with left hemisphere infarctions (16 versus 2 unconscious patients of the right hemisphere, Frequency: 72%, GCS: 2/10=3/22 cases, GCS: 5/10=1/22 cases, GCS: 6-7/10=12/22 cases). The difference in unconsciousness proved significant in Fisher’s exact analysis (p-value = 0.001) and remained independent of age (p-value=0.7247) and gender (p-value=0.3145). Moreover, six conscious patients with left hemisphere involvement exhibited a loss of conscious control for normal responses, implying a strong link between consciousness and cognition. Unconsciousness also correlated with stroke outcomes (16 Unconscious: 56.25% deceased within the hospital). Conclusion. Conscious processes are more predominant in the brain\u27s left hemisphere. Our observations indicate that only a gross unilateral insult to the brain can lead to unconsciousness

Post Thrombolytic St-Segment Resolution Outcome in Acute Myocardial Infarction Patients

OBJECTIVES: The main objective of this study was to assess post thrombolytic resolution of ST-segment and its outcome in patients with acute myocardial infarction. METHODOLOGY: This Prospective Comparative Study was carried out at the Cardiology Unit of Ayub Teaching Hospital, Abbottabad. All patients irrespective of gender and age with ST-Segment elevation myocardial infarction (STEMI), having no immediate access to angioplasty and thrombolysed with streptokinase, were included in this study. ECG was taken at the beginning and 90 minutes after the administration of streptokinase. Based on ST-segment resolution on ECG taken at 90 minutes these patients were classified into group A and B. Group A included patients with ST-segment resolution while group B showed no resolution of ST-segment after streptokinase administration. These patients were followed during their hospital stay for complications such as arrhythmias, cardiogenic shock, acquired ventricular septal defects (VSD) aneurysm and death. RESULTS: Among 115 patients, 94 were male and 21 female. Group A included 102 (89%) patients and group B included 13 (11%). In group A, only 1 (0.98 %) patient developed complications and in group B, 13 patients (100%) developed complications. Arrhythmias were the most common complication among MI patients in group A while cardiogenic shock was the commonest complication in group B. CONCLUSION: ST-segment resolution is a practical and applicable indicator of successful thrombolysis and has a significant correlation with clinical outcome in acute myocardial patients after thrombolysis with streptokinase

The Relationship between Ethical Leadership and Whistle-Blowing: The Moderating Effects of Job Security and Affective Commitment

The present study examines the positive impact of ethical leadership on whistleblowing. The study further investigates the role of job security and affective commitment as moderators on the relationship between ethical leadership and whistleblowing. This study examined the fundamental moderating mechanism, which is unique because no such mechanism has been investigated in previous research. A cross-sectional representative sample of 285 Federal Government employees from various Ministries/Divisions and the Benazir Income Support Programme, a corporate body and a renowned social safety net under the Federal Government of Pakistan, was collected. Of the 285 questionnaires, only 241 were deemed useable and were analyzed. A statistical analysis was carried out through correlation, descriptive, and moderated regression analysis. The results supported the first three hypotheses that ethical leadership and whistleblowing had a positive relationship. Furthermore, job security moderated the positive relationship between ethical leadership and whistleblowing, such that the relationship is stronger for employees with high job security and weaker for employees with low job security. Affective commitment also moderated the relationship directly meaning that the relationship is stronger when the affective commitment is strong and weaker when it is weak. Discussion, implications, limitations, and future directions have been suggested in accordance with the results of the study

GENDER DIFFERENCES IN LEADERSHIP

Gender differences have always been debated in a lot of platforms including in universities. In universities, both female and male leaders are being proactive with their advocacies in their own leadership pursuits in which at the same time they have to focus on their academic performances as well. Some questions may arise: how do they handle both of these pursuits at the same time? Will they portray any differences in balancing of these pursuits? Research has proven that gender differences do exist between male and female leaders especially in the aspect of leadership, academic performances and the ability of them to do multi-tasking and interestingly, this particular research has been in the favour of female leaders.In this research paper, gender differences will be determined between male leaders of Jawatankuasa Perwakilan Kolej Delima and female leaders of Jawatankuasa Perwakilan Kolej Melati, in which both of these organisations are recognized as the most victorious organisations of all residential colleges in UiTM Shah Alam. A quantitative method has been applied in the commission of this research whereby it requires 34 respondents from both organisations to answer a questionnaire. From this research, it has been found that even though prior research made by the previous researchers was in the favour of female leaders, but, male leaders of Jawatankuasa Perwakilan Kolej Delima tend to show that they could create equilibrium in both of the pursuits that they have involved in, compared to female leaders of Jawatankuasa Perwakilan Kolej Melati. A qualitative method in the form of interview also has been conducted in order to obtain thorough insights of what have been transpired by all of them in pursuing both of the pursuits. Albeit of the disparities, all of the respondents share the same attributes in which they are persevere, brave, courageous and strong to find equilibrium between both of the pursuit as their interpretation of being a victorious leader is being a survivor, not a quitter. All in all, both female and male leaders of respondents are in the pursuit of being a victorious leader as the definition of „victorious leader‟ for them are being a survivior in facing all of the ruthless and dreadful challenges of being a leader

Structural Performance of GFRP Bars based High-Strength RC Columns: An Application of Advanced Decision-Making Mechanism for Experimental Profile Data

Several past studies have shown the use of glass fibre-reinforced polymer (GFRP) bars to alleviate the reinforced steel rusting issue in different concrete structures. However, the practise of GFRP bars in concrete columns has not yet achieved a sufficient confidence level due to the lack of a theoretical model found in the literature. The objective of the current study is to introduce a novel prediction model for the axial capability of concrete columns made with bars of GFRP. For this purpose, two different approaches, such as data envelopment analysis (DEA) and artificial neural networks (ANNs) modelling, are used on a collected dataset of 266 concrete column specimens made with GFRP bars from previous literature works. Eight parameters were used to predict the axial performance of GFRP-based RC columns. The proposed DEA and ANNs predictions demonstrated a good correlation with the testing dataset, having R2 values of 0.811 and 0.836, respectively. A comparative analysis of the DEA and ANNs models is undertaken, and it was found that the suggested models are capable of accurately forecasting the structural response of GFRP-made RC column structures. Then, a comprehensive parametric analysis of 266 GFRP-based columns was performed to study the effect of different materials and their geometrical shape.publishedVersio